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  • Title: [Analysis of Foxp3+ CD4+ CD25+ regulatory cells in peripheral blood of patients with SLE].
    Author: Wei HG, Cai B, Wang LL, Li J, Feng WH.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2007 May; 23(5):432-5. PubMed ID: 17488604.
    Abstract:
    AIM: To investigate the expression of GITR on T cells and the expression of Foxp3(+) CD4(+) CD25(+) regulatory T cells in the peripheral blood of patients with SLE. METHODS: The expression of GITR and Foxp3(+) CD4(+) CD25(+) regulatory T cells in the peripheral blood was determined by flow cytometry(FCM). RESULTS: Compared with health control, the expression of Foxp3(+) CD4(+) CD25(+) regulatory T cells in peripheral blood from SLE patients was lower (P<0.05), but there is no difference in the expression of Foxp3(+) CD4(+) CD25(+) regulatory T cells between active and inactive SLE patients (P>0.05). GITR expression on both CD3(+) CD4(+) T cells and CD3(+) CD8(+) T cells of SLE patients increased significantly (P>0.05). With the development of SLE activity, GITR expression didn't change significantly on both CD3(+) CD4(+) T cells (P>0.05) and CD3(+) CD8(+) T cells (P>0.05). CONCLUSION: The expression abnormality of both Foxp3(+) CD4(+) CD25(+) regulatory cells and GITR may play important role in the imbalance of immune homeostasis in SLE.
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