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  • Title: [Levels of estrogen and progesterone receptors in premalignant and malignant states in the endometrium].
    Author: Jokanović L, Cvrtila D, Klarić P, Kanajet D.
    Journal: Jugosl Ginekol Perinatol; 1991; 31(3-4):49-51. PubMed ID: 1749274.
    Abstract:
    In a prospective study conducted from 1981 to 1989, concentrations of estrogen (ER) and progesterone (PR) receptors were determined by the saturation analysis of cytosols prepared from 67 samples of human endometrial tissue. Patients over 35 years of age who had come to the hospital because of irregular bleeding were included in the investigation. In the group examined it was found that 25 patients developed endometrial carcinoma, 22 hyperplasia adenomatosa and 20 patients had normal pathohistological findings. The median values of ER concentrations were 46, 99 and 31 fmol/mg of protein, with the ranges of 0-628, 0-2348 and 0-552 fmole/mg of protein in the group with normal endometrial tissue, hyperplastically transformed endometrial tissue and in the group with endometrial carcinoma, respectively. The median values of PR concentrations were 196, 307 and 96 fmol/mg of protein, with the ranges of 0-1714, 0-2402 and 0-582 fmole/mg of protein in the group with normal endometrial tissue, hyperplastically transformed endometrial tissue and in the group with endometrial carcinoma, respectively. In the group of patients with endometrial carcinoma 40% of ER+/PR+ tumors (greater than 50 fmole/mg of protein), 36% of ER-/PR-tumors, and 24% of ER-/PR+ tumors were found. The results of the median test showed that there were no statistically significant differences among ER concentrations (chi 2 = 2.822; P = 0.2439), or among PR concentrations (chi 2 = 3.582; P = 0.1668) in the groups of patients examined.
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