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  • Title: Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness.
    Author: Iwamura C, Kimura MY, Shinoda K, Endo Y, Hasegawa A, Yamashita M, Nakayama T.
    Journal: Int Immunol; 2007 Jun; 19(6):755-62. PubMed ID: 17493960.
    Abstract:
    Schnurri (Shn)-2 is a large zinc finger-containing protein, which plays a critical role in cell growth, signal transduction and lymphocyte development. In Shn-2-deficient (Shn-2(-/-)) CD4 T cells, the activation of nuclear factor-kappaB is up-regulated and their ability to differentiate into Th2 is enhanced. Here, we extend our investigation and demonstrate that Shn-2 regulates Th2 responses in vivo using an ovalbumin-induced allergic asthma model. Eosinophilic inflammation, mucus hyperproduction and airway hyperresponsiveness (AHR) were all enhanced in Shn-2(-/-) mice. Moreover, eosinophilic infiltration and AHR were enhanced in mice given a transfer of Shn-2(-/-) effector Th2. Shn-2 in Th2 is thus considered to play an important role as a negative regulator in allergic airway inflammation.
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