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  • Title: A neuropsychological profile of off-diet adults with phenylketonuria.
    Author: Moyle JJ, Fox AM, Bynevelt M, Arthur M, Burnett JR.
    Journal: J Clin Exp Neuropsychol; 2007 May; 29(4):436-41. PubMed ID: 17497567.
    Abstract:
    The metabolic disorder phenylketonuria (PKU) is treated early by a low-phenylalanine diet. While this prevents global cognitive impairment, some patients still experience cognitive and neurophysiological abnormalities. Neuropsychological testing of early treated, currently off-diet, PKU patients attending an adult PKU clinic showed a reduction in the Perceptual Organization Index (POI), Processing Speed Index (PSI) from the Wechsler Adult Intelligence Scale Third Edition (WAIS-III), and Part A of the Trail Making Test for the PKU group relative to controls. Taken together, these results supported a profile of reduced information-processing speed.
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