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  • Title: Preoperative lymph-vascular space invasion is associated with nodal metastases in women with early-stage cervical cancer.
    Author: Milam MR, Frumovitz M, dos Reis R, Broaddus RR, Bassett RL, Ramirez PT.
    Journal: Gynecol Oncol; 2007 Jul; 106(1):12-5. PubMed ID: 17498783.
    Abstract:
    OBJECTIVE: To determine the association between findings on review of preoperative biopsy specimens and the risk of lymph node involvement (LNI) at radical hysterectomy in patients with early-stage cervical cancer. METHODS: Eighty-one patients were included in this retrospective review. Preoperative biopsy features evaluated were stage, grade, histologic subtype, lymph-vascular space invasion (LVSI), and depth (>4 mm) of invasion. RESULTS: Twelve patients (14.8%) had LNI at radical hysterectomy. Stage, grade, and histologic subtype were not associated with LNI. LVSI and depth of invasion >4 mm were both significantly associated with LNI (25.6% vs. 4.8%, P=0.01, and 25.0% vs. 4.5%, P=0.01, respectively). LVSI with >4 mm invasion was 6.6 times more likely to have LNI at the time of radical hysterectomy (RR=6.6; 95% confidence interval, 2.1-21.9). CONCLUSION: Patients with preoperative LVSI are at higher risk for LNI at radical hysterectomy and should be counseled regarding potential implications for management.
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