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  • Title: A general and efficient five-step one-pot procedure leading to nitrogen-bridgehead heterocycles containing an imidazole ring.
    Author: Parenty AD, Song YF, Richmond CJ, Cronin L.
    Journal: Org Lett; 2007 Jun 07; 9(12):2253-6. PubMed ID: 17500559.
    Abstract:
    A very simple annulation reaction was designed, allowing an imidazole moiety to be fused onto a range of pyridine-based derivatives. The methodology consists of an activation step via the formation of a pyridinium salt to increase the electrophilicity of the pyridine ring, followed by a cascade reaction triggered by a nucleophilic attack of the iminium moiety. Depending on the pyridinium salt, it is possible to obtain functionalized imidazole moieties.
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