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  • Title: Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B.
    Author: Morrison DC, Jacobs DM.
    Journal: Infect Immun; 1976 Jan; 13(1):298-301. PubMed ID: 175019.
    Abstract:
    Treatment of bacterial lipopolysaccharides (endotoxins) isolated from Salmonella minnesota R595 or purified lipid A with the antibiotic polymyxin B has been demonstrated to abrogate the ability of these molecules to activate serum complement. The inhibition is a function of the ratio of polymyxin B to lipopolysaccharide.
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