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  • Title: [Stable reduction of endogenous insulin production in the body in experimental insulin-dependent diabetes].
    Author: Kudriashov BA, Ul'ianov AM.
    Journal: Vopr Med Khim; 1991; 37(4):40-3. PubMed ID: 1750208.
    Abstract:
    Implantation of beta-cells allogenic culture into animals with alloxan diabetes did not produce persistent positive effect. The implanted beta-cells lost their viability as a result of toxic effect of natural diabetogenic factor occurring in blood plasma during insulin-dependent diabetes. Long-term administration of heparin into these animals within first 90 days of the experiment enabled to avoid the negative phenomenon and to neutralize the diabetogenic factor activity. Under these conditions the implanted beta-cells effectively produced endogenous insulin and the symptoms of diabetes disappeared within 14 months.
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