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  • Title: [Prostaglandin E1 in therapy of peripheral arterial occlusive disease].
    Author: Sinzinger H, Rogatti W.
    Journal: Wien Klin Wochenschr; 1991; 103(18):558-65. PubMed ID: 1750223.
    Abstract:
    The intraarterial and intravenous infusion of prostaglandin E1 (PGE1) today is well established in the therapy of peripheral arterial occlusive disease. This review summarizes the results of pharmacological-clinical studies and the influence of PGE1 on the pathomechanism of ischaemia due to its antithrombotic, leukocyte and endothelial stabilizing properties. Clinical data available on continuous and intermittent infusion for both modes of administration are critically appraised, taking into account more recent data on active metabolites.
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