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Title: The first limonoid peroxide in the Meliaceae family: walsuronoid A from Walsura robusta. Author: Yin S, Wang XN, Fan CQ, Liao SG, Yue JM. Journal: Org Lett; 2007 Jun 07; 9(12):2353-6. PubMed ID: 17503836. Abstract: Walsuronoid A (1), a limonoid featuring an unprecedented 3,4-peroxide-bridged A-seco skeleton, together with walsuronoids B (2) and C (3) possessing a rare 18(13-->14)-abeo-limonoid skeleton, was isolated from Walsura robusta. The structures were elucidated by spectroscopic analysis and chemical correlation, and that of 1 was confirmed by single-crystal X-ray diffraction. Biosynthetic pathway of 2 and 3 was proposed and was chemically mimicked. Compounds 1 and 2 showed weak antimalarial activity.[Abstract] [Full Text] [Related] [New Search]