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  • Title: Efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones via the Vilsmeier-Haack reaction of 1-acetyl,1-carbamoyl cyclopropanes.
    Author: Pan W, Dong D, Wang K, Zhang J, Wu R, Xiang D, Liu Q.
    Journal: Org Lett; 2007 Jun 07; 9(12):2421-3. PubMed ID: 17503843.
    Abstract:
    A facile and efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones is developed via the Vilsmeier-Haack reaction of readily available 1-acetyl,1-carbamoyl cyclopropanes, and a mechanism involving sequential ring-opening, haloformylation, and intramolecular nucleophilic cyclization reactions is proposed.
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