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  • Title: Non-homologous DNA end joining in anticancer therapy.
    Author: Pastwa E, Malinowski M.
    Journal: Curr Cancer Drug Targets; 2007 May; 7(3):243-50. PubMed ID: 17504121.
    Abstract:
    Non-homologous DNA end joining (NHEJ) is the major pathway for the repair of double-strand breaks (DSBs) in human cells. Proteins involved in NHEJ pathway can become molecular targets in the treatment of cancer. Inhibition of this pathway leads to radio- and chemosensitization of cancer cells. This review will focus on the new therapeutic strategies for NHEJ pathway inhibition and their application in anticancer therapy.
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