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  • Title: E-cadherin, beta-catenin, invasion and lymph node metastases in canine malignant mammary tumours.
    Author: De Matos AJ, Lopes CC, Faustino AM, Carvalheira JG, Rutteman GR, Gärtner Mde F.
    Journal: APMIS; 2007 Apr; 115(4):327-34. PubMed ID: 17504299.
    Abstract:
    Recent studies of canine malignant mammary tumours suggest that reduction of E-cadherin and/or beta-catenin correlates with invasive behaviour and lymph node metastasis. The aims of this study were to examine the interrelationships between the expression of E-cadherin and beta-catenin, and the relationship between the expression of E-cadherin and/or beta-catenin and the mode of growth and metastatic capacity of canine malignant mammary tumours. 90 spontaneous malignant tumours and local and regional lymph nodes were studied. A significant relationship was evidenced between membranous expression of E-cadherin and beta-catenin (p=0.0027), but not between E-cadherin and cytoplasmic beta-catenin. Only E-cadherin as a separate factor was significantly related to tumour invasion (p=0.0072) and lymph node metastasis (p=0.0001). Neither membranous nor cytoplasmic beta-catenin expression was significantly related to either of these phenomena.
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