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  • Title: [Exposure of normal Tenon's capsule fibroblasts from pterygium to 5-fluorouracil and mitomycin C].
    Author: Viveiros MM, Schellini SA, Candeias J, Padovani CR.
    Journal: Arq Bras Oftalmol; 2007; 70(1):73-7. PubMed ID: 17505723.
    Abstract:
    PURPOSE: To evaluate the fibroblast proliferation activity of normal Tenon's capsule from primary and recurrent patients with pterygium. METHODS: A randomized prospective study was performed with 41 normal Tenon's capsule fragments from 21 primary and 20 recurrent patients with pterygium. The sample was collected from the inferior cul-de-sac. Proliferation rate from fibroblasts were evaluated after mitomycin C and 5-fluorouracil exposition. Data were submitted to statistical analysis. RESULTS: Of the 41 cultivated normal Tenon's capsules, only 1 from primary and 2 from recurrent pterygium patients proliferated. After antimitotic exposition, the proliferation rate was similar with both drugs. CONCLUSION: Mitomycin and 5-fluorouracil promote similar inhibition regarding proliferation of normal Tenon's fibroblast cultures.
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