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  • Title: Comparing two independent incidence rates using conditional and unconditional exact tests.
    Author: Han C.
    Journal: Pharm Stat; 2008; 7(3):195-201. PubMed ID: 17506083.
    Abstract:
    Several unconditional exact tests, which are constructed to control the Type I error rate at the nominal level, for comparing two independent Poisson rates are proposed and compared to the conditional exact test using a binomial distribution. The unconditional exact test using binomial p-value, likelihood ratio, or efficient score as the test statistic improves the power in general, and are therefore recommended. Unconditional exact tests using Wald statistics, whether on the original or square-root scale, may be substantially less powerful than the conditional exact test, and is not recommended. An example is provided from a cardiovascular trial.
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