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  • Title: Change in heart rate variability in relation to a significant ST-event associates with newborn metabolic acidosis.
    Author: Siira S, Ojala T, Ekholm E, Vahlberg T, Blad S, Rosén KG.
    Journal: BJOG; 2007 Jul; 114(7):819-23. PubMed ID: 17506791.
    Abstract:
    OBJECTIVE: To find whether low-to-high frequency (LF/HF) ratio of fetal heart rate (FHR) variability changes in relation to a significant ST-event during delivery, and if the change is predictive of metabolic acidosis of the newborn. DESIGN: A case-control study. SETTING: Data from a multicentre project. SUBJECTS: Acidotic and control fetuses with abnormal cardiotocography together with a ST-event in fetal electrocardiogram (ECG). METHODS: We studied intrapartum FHR variability with spectral analysis from 34 fetuses with a significant ST-event in the fetal ECG. LF/HF ratio of FHR variability was measured within a period of 1 hour before and 1 hour after a significant ST-event. Sensitivity and specificity of the change in LF/HF ratio of FHR variability in prediction of metabolic acidosis (pH < or = 7.05 and base deficit value > 12.0 mmol/l) of the newborn were described by means of the receiver operating characteristic curve. MAIN OUTCOME MEASURES: Change in LF/HF ratio of FHR in relation to a significant ST-event. RESULTS: We found that a relative change in LF/HF ratio greater than 30% in relation to a significant ST-event predicted cord arterial metabolic acidosis with a sensitivity of 89% (95% CI 68-100%) and specificity of 80% (95% CI 64-96%). CONCLUSIONS: Relative changes in LF/HF ratio of FHR variability in relation to a significant ST-event are more pronounced in fetuses born with metabolic acidosis.
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