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Title: PCR-restriction fragment length polymorphism analysis of Campylobacter jejuni genes involved in lipooligosaccharide biosynthesis identifies putative molecular markers for Guillain-Barré syndrome. Author: Godschalk PC, van Belkum A, van den Braak N, van Netten D, Ang CW, Jacobs BC, Gilbert M, Endtz HP. Journal: J Clin Microbiol; 2007 Jul; 45(7):2316-20. PubMed ID: 17507514. Abstract: Molecular mimicry of Campylobacter jejuni lipooligosaccharides (LOS) by gangliosides in peripheral nerve tissue probably triggers the Guillain-Barré syndrome due to the induction of cross-reactive antibodies. PCR-restriction fragment length polymorphism analysis of C. jejuni genes involved in the biosynthesis of LOS demonstrated that specific genes were associated with the expression of ganglioside mimics and the development of neuropathy.[Abstract] [Full Text] [Related] [New Search]