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  • Title: SPUU-PEO-heparin graft copolymer surfaces. Patency and platelet deposition in canine small diameter arterial grafts.
    Author: Kim WG, Park KD, Mohammad SF, Kim SW.
    Journal: ASAIO Trans; 1991; 37(3):M148-9. PubMed ID: 1751086.
    Abstract:
    The influence of an SPUU-PEO-Heparin (B-PEO-HEP) copolymer coated blood contacting surface on patency and platelet deposition in small diameter (4 mm i.d.) Biomer grafts was investigated using a canine model. Grafts were implanted in the bilateral carotid and femoral arteries. B-PEO-HEP coated grafts still showed patency after 3 days. Control Biomer grafts occluded before 24 hr. (postoperatively). SEM of the luminal surfaces of the Biomer grafts demonstrated large amounts of adherent platelets with distorted morphologies, while B-PEO-HEP grafts did not. In platelet studies, B-PEO-HEP grafts showed significantly less platelet adhesion than Biomer grafts. The improved blood compatibility of B-PEO-HEP graft co-polymer coatings attests to their usefulness for coating or casting.
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