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  • Title: [Study on separation and purification of total alkaloids and mesaconitine with X - 5 macroporous resin].
    Author: Li WL, Wang YP, Ji YB, Fang YQ, Zhao P.
    Journal: Zhongguo Zhong Yao Za Zhi; 2007 Mar; 32(5):396-400. PubMed ID: 17511143.
    Abstract:
    OBJECTIVE: To study systematically the factors which affect separation and purification of the total alkaloids and mesaconitine with X -5 macroporous resin. METHOD: With the content of the total alkaloids and mesaconitine as parameters, the optimum condition of absorption and elution were studied in the process of the purification with X -5 macroporous resin. RESULT: The X - 5 macroporous resin yielded the best separating efficiency when the concentration of the extracted solution was 1 g raw material per 1 mL, pH 12.0, the absorptive time of 6 hour and the volume of 95% ethanol (7BV pH 8) as the eluant; X -5 macroporous resins was used five times in a reproducible way. The rate of extraction and content of the total alkaloid were 80% and 30% respectively after purification with X - 5 macroprous resin. CONCLUSION: The method can increase the purity of mesaconitine and total alkaloids.
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