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  • Title: Synthesis and NMR experiments of (4,5,6-13C)-deoxymannojirimycin. A new entry to 13C-labeled glycosidase inhibitors.
    Author: Murruzzu C, Alonso M, Canales A, Jiménez-Barbero J, Riera A.
    Journal: Carbohydr Res; 2007 Sep 03; 342(12-13):1805-12. PubMed ID: 17511974.
    Abstract:
    The synthesis of (4,5,6-13C)-deoxymannojirimycin is described. The route employed is based on Sharpless asymmetric epoxidation of (1,2,3-13C)(E)-2,4-pentadien-1-ol and uses ring-closing metathesis as a key step. The labeled compound may be easily used for protein-binding experiments using NMR spectroscopic methods.
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