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  • Title: Guiding ligands to nuclear receptors.
    Author: Michalik L, Wahli W.
    Journal: Cell; 2007 May 18; 129(4):649-51. PubMed ID: 17512397.
    Abstract:
    Retinoic acid-the active metabolite of vitamin A-influences biological processes by activating the retinoic acid receptor (RAR). In this issue, Schug et al. (2007) demonstrate that retinoic acid also activates the peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta). Remarkably, retinoic acid signaling through RAR or PPARbeta/delta-which depends on cytoplasmic retinoic acid transporters-commits the cell to opposite fates, apoptosis or survival, respectively.
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