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  • Title: Inhibition of matrix metalloproteinase-9 activity by lisinopril after myocardial infarction in hamsters.
    Author: Takai S, Yamamoto D, Jin D, Inagaki S, Yoshikawa K, Tanaka K, Miyazaki M.
    Journal: Eur J Pharmacol; 2007 Jul 30; 568(1-3):231-3. PubMed ID: 17512521.
    Abstract:
    We measured angiotensin-converting enzyme and matrix metalloproteinase-9 activities after myocardial infarction in hamsters and compared the effects of an angiotensin-converting enzyme inhibitor lisinopril with those of an angiotensin receptor blocker candesartan cilexetil after myocardial infarction. Angiotensin-converting enzyme activity was significantly increased 3 and 7 days, but not 1 day after myocardial infarction. Matrix metalloproteinase-9 activity was significantly increased 1 day after myocardial infarction. Lisinopril significantly inhibited both angiotensin-converting enzyme and matrix metalloproteinase-9 activities, but candesartan cilexetil did not. Angiotensin-converting enzyme inhibitors might directly inhibit matrix metalloproteinase-9 activity.
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