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  • Title: Cytotoxic dibromotyrosine-derived metabolites from the sponge Aplysina gerardogreeni.
    Author: Hernández-Guerrero CJ, Zubía E, Ortega MJ, Carballo JL.
    Journal: Bioorg Med Chem; 2007 Aug 01; 15(15):5275-82. PubMed ID: 17512741.
    Abstract:
    The chemical study of the sponge Aplysina gerardogreeni collected at the Gulf of California has led to the isolation of four new dibromotyrosine-derived metabolites, aplysinones A-D, whose structures were determined by spectroscopic analysis and chemical methods. The new compounds and four semisynthetic analogues prepared in this study have shown cytotoxic activity against human tumor cell lines.
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