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  • Title: The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking.
    Author: Mousley CJ, Tyeryar KR, Vincent-Pope P, Bankaitis VA.
    Journal: Biochim Biophys Acta; 2007 Jun; 1771(6):727-36. PubMed ID: 17512778.
    Abstract:
    A central principle of signal transduction is the appropriate control of the process so that relevant signals can be detected with fine spatial and temporal resolution. In the case of lipid-mediated signaling, organization and metabolism of specific lipid mediators is an important aspect of such control. Herein, we review the emerging evidence regarding the roles of Sec14-like phosphatidylinositol transfer proteins (PITPs) in the action of intracellular signaling networks; particularly as these relate to membrane trafficking. Finally, we explore developing ideas regarding how Sec14-like PITPs execute biological function. As Sec14-like proteins define a protein superfamily with diverse lipid (or lipophile) binding capabilities, it is likely these under-investigated proteins will be ultimately demonstrated as a ubiquitously important set of biological regulators whose functions influence a large territory in the signaling landscape of eukaryotic cells.
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