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  • Title: HPLC quantification of perphenazine in sheep plasma: application to a pharmacokinetic study.
    Author: Pedernera C, Ruiz JL, Castells G, Manteca X, Cristòfol C.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2007 Jul 01; 854(1-2):308-12. PubMed ID: 17512805.
    Abstract:
    A high performance liquid chromatographic (HPLC) method for the determination of perphenazine (PPZ) in sheep plasma was developed and validated. The separation was achieved using a 5 microm C18 column (125 mm x 4 mm) with a mobile phase composed of acetonitrile and an aqueous solution of H(3)PO(4) and TBA (inverse gradient). The flow rate was 1.5 mL/min and the UV detection was performed at 258 nm. The method was validated with respect to linearity, intra and inter-day precision and accuracy, limit of quantification, limit of detection and storage stability. This method was used to perform a pilot pharmacokinetic study of PPZ after subcutaneous administration to one ewe.
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