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  • Title: Randomized clinical trial of single- versus multiple-dose antimicrobial prophylaxis in gastric cancer surgery.
    Author: Mohri Y, Tonouchi H, Kobayashi M, Nakai K, Kusunoki M, Mie Surgical Infection Research Group.
    Journal: Br J Surg; 2007 Jun; 94(6):683-8. PubMed ID: 17514671.
    Abstract:
    BACKGROUND: The optimum duration of antimicrobial prophylaxis in elective gastric cancer surgery is still open to question. This multicentre randomized clinical trial compared a single-dose with a multiple-dose regimen of antimicrobial prophylaxis for prevention of surgical-site infection. METHODS: Between May 2001 and December 2004, 501 patients undergoing elective surgery for gastric cancer in ten centres were allocated randomly to single- or multiple-dose antimicrobial prophylaxis. The primary outcome measure was the incidence of surgical-site infection, analysed by intention to treat. RESULTS: Some 243 patients who received a single dose and 243 who received multiple doses of antibiotics were included in the final analysis. The surgical-site infection rate was 9.5 per cent (23 of 243) and 8.6 per cent (21 of 243) respectively (difference 0.9 (95 per cent confidence interval - 4.3 to 5.9) per cent). Antimicrobial prophylaxis had no major adverse effects. CONCLUSION: The incidence of surgical-site infection in elective gastric cancer surgery was similar with both antibiotic prophylaxis regimens.
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