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  • Title: Solubility of selected derivatives of 1,4-benzodiazepin-2-one in solid dispersions in PEG 6000.
    Author: Cwiertnia B.
    Journal: Acta Pol Pharm; 2006; 63(2):135-9. PubMed ID: 17514877.
    Abstract:
    Pharmaceutical availability of diazepam, oxazepam and nitrazepam from solid dispersions of PEG 6000 have been studied in comparison with corresponding physical mixtures and pure benzodiazepines. Selected derivatives of 1,4-benzodiazepin-2-one are poorly water soluble drugs. The aim of this work was to report the properties of diazepam- and nitrazepam-PEG 6000 solid dispersions. Differential scanning calorimetry (DSC) and X-ray diffraction were used to characterize the solid dispersions. The effect of PEG 6000 on the dissolution of selected derivatives of 1,4-benzodiazepin-2-one was investigated. The dissolution of diazepam, oxazepam and nitrazepam from its solid dispersions increased in the presence of PEG 6000.
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