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  • Title: Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps.
    Author: Li SC, Burgart L.
    Journal: Arch Pathol Lab Med; 2007 Mar; 131(3):440-5. PubMed ID: 17516746.
    Abstract:
    CONTEXT: Serrated adenomas can be morphologically subdivided into traditional and sessile types. They are thought to have a comparable rate of cancer progression like conventional adenomas, but they potentially have a faster rate of growth through methylation pathway(s). They share similar morphologic features with both the conventional adenoma and the hyperplastic polyp in a fashion that is different from a mixed adenoma and a hyperplastic polyp. OBJECTIVE: To describe the histopathologic features of traditional serrated adenoma and sessile serrated adenoma and their comparison with traditional adenomas and hyperplastic polyp. DATA SOURCES: Relevant articles in peer-review journals and the authors' working experience as practicing surgical pathologists with a specific interest in gastrointestinal pathology. CONCLUSIONS: Both types of serrated adenomas, traditional serrated adenoma and sessile serrated adenoma, are morphologically distinct, clinically important entities, and they can be diagnosed accurately in routine practice.
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