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  • Title: In vitro maturation of germinal vesicle oocytes recovered after premature luteinizing hormone surge: description of a novel approach to fertility preservation.
    Author: Oktay K, Demirtas E, Son WY, Lostritto K, Chian RC, Tan SL.
    Journal: Fertil Steril; 2008 Jan; 89(1):228.e19-22. PubMed ID: 17517403.
    Abstract:
    OBJECTIVE: To report a novel approach to fertility preservation by in vitro maturation and embryo cryopreservation after LH surge and ovulation. DESIGN: Case report. SETTING: Two university-based reproductive endocrinology clinics. PATIENT(S): Forty-year-old woman with breast cancer seeking fertility preservation before chemotherapy. INTERVENTION(S): The plan was ovarian stimulation and retrieval of mature oocytes, followed by IVF; however, premature LH surge and ovulation occurred before oocyte retrieval. Because no mature oocyte was recovered, follicles <10 mm in diameter were also aspirated. MAIN OUTCOME MEASURE(S): Recovery of immature oocytes after ovulation, in vitro maturation of these oocytes, and fertilization and vitrification of generated embryos. RESULT(S): Four immature oocytes were recovered, and two matured in vitro. After fertilization with intracytoplasmic sperm injection, embryos progressed to the four-cell stage on day 2 and were vitrified for future use. CONCLUSION(S): This case illustrates that under time constraints, immature oocytes can be recovered after ovulation and used to generate embryos for fertility preservation.
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