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  • Title: Solid-phase synthesis of carboxylic and oxamic acids via OsO4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides.
    Author: Nielsen TE, Le Quement ST, Meldal M.
    Journal: Org Lett; 2007 Jun 21; 9(13):2469-72. PubMed ID: 17518476.
    Abstract:
    A general method for the solid-phase synthesis of carboxy-functionalized peptides by oxidative cleavage of alkynes is presented. Clean and quantitative conversion is enabled by the addition of bases, such as DABCO and HMTA, to the classical OsO4/NaIO4 mixture. The utility of the reaction is further illustrated by the synthesis of oxamic acids.
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