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  • Title: Evaluation of major membrane protein-II as a tool for serodiagnosis of leprosy.
    Author: Maeda Y, Mukai T, Kai M, Fukutomi Y, Nomaguchi H, Abe C, Kobayashi K, Kitada S, Maekura R, Yano I, Ishii N, Mori T, Makino M.
    Journal: FEMS Microbiol Lett; 2007 Jul; 272(2):202-5. PubMed ID: 17521364.
    Abstract:
    As serodiagnosis is the easiest way of diagnosing a disease, the utility of Mycobacterium leprae-derived major membrane protein-II (MMP-II), one of the immuno-dominant antigens, in the serodiagnosis of leprosy was examined. The percent positivity by an enzyme-linked immunosorbent assay for anti-MMP-II antibody was 82.4% for multi-bacillary leprosy, and the specificity of the test was 90.1%. For pauci-bacillary leprosy where cell-mediated immunity predominates, 39.0% showed positive results. These percentage values were significantly higher than these values obtained for existing phenolic glycolipid-I based methods, suggesting that MMP-II antibody detection would facilitate the diagnosis of leprosy.
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