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  • Title: [Relationship between free radicals and diabetic microangiopathy].
    Author: Li H, Tang ZH, Xia TQ.
    Journal: Zhonghua Nei Ke Za Zhi; 1991 Jul; 30(7):402-4, 455. PubMed ID: 1752151.
    Abstract:
    Lipid peroxide (LPO) values in blood plasma, along with the glutathione peroxidase (GSH-PX) activity in whole blood and superoxide dismutase (SOD) activity in erythrocytes were determined in 50 patients with non-insulin-dependent diabetes mellitus (NIDDM) and in 33 control subjects. The mean LPO value, SOD activity, LPO/GSH-PX and LPO/SOD ratios in the diabetic patients were significantly higher than those in the control subjects. The increases of LPO value, LPO/GSH-PX and LPO/SOD ratios were more pronounced in diabetics with microangiopathy than in those without microangiopathy. Our results suggest that free radicals may be implicated in the pathogenesis of diabetic microangiopathy.
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