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  • Title: [Heat-shock protein 27 linked to multi-drug resistance in human hepatic cancer cell lines].
    Author: Peng SF, Fu L, Tan DM.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2007 May; 15(5):362-5. PubMed ID: 17524270.
    Abstract:
    OBJECTIVE: A proteomics approach was applied for finding multi-drug resistance (MDR) related proteins in hepatic cancer cell lines. METHODS: Two-dimensional electrophoresis (2-DE) was used to separate the total proteins of vincristine-resistant hepatic cancer cell line HepG2/VCR and its counterpart HepG2. The differential expression proteins between the two cell lines were identified by both MALDI-TOF-MS and ESI-Q-TOF-MS. Heat-shock protein 27 (HSP27), one of the differential expression proteins in the development of MDR of HepG2/VCR, was analyzed by HSP27 antisense oligonucleotides (ASOs). RESULTS: As a high expression protein in HepG2/VCR, HSP27 was identified, and the suppression of HSP27 expression by HSP27 ASO enhanced the vincristine chemosensitivity of HepG2/VCR (P less than 0.05). CONCLUSION: HSP27 is linked to MDR in human hepatic cancer cell line HepG2/VCR.
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