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  • Title: High FVIII level is associated with idiopathic portal vein thrombosis in South India.
    Author: Koshy A, Jeyakumari M.
    Journal: Am J Med; 2007 Jun; 120(6):552.e9-11. PubMed ID: 17524760.
    Abstract:
    BACKGROUND: In the majority of the cases of portal vein thrombosis in India, the etiology cannot be determined. A high level of factor VIII (FVIII) is a risk factor for venous thromboembolism. METHODS: In this study from South India, FVIII was estimated in 32 patients with idiopathic portal vein thrombosis (PVT), 12 healthy controls and 12 disease controls with chronic liver disease. RESULTS: Eighty-four percent of the patients with portal vein thrombosis (27/32) vs 17% of healthy controls (2/12) had high factor VIII levels (P <.0001). FVIII levels were significantly different between the subset of PVT patients with normal liver function compared with healthy controls (P <.001) and also between the subset of PVT patients with abnormal liver function compared with disease controls (P <.05). CONCLUSIONS: A high factor VIII level seems to contribute to the development of portal vein thrombosis in India.
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