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  • Title: [Study of the conformational changes of serum albumin molecules within a pre-denaturation temperature range by a spin probe technique].
    Author: Kuznetsov AN, Ebert B.
    Journal: Mol Biol (Mosk); 1975; 9(3):407-14. PubMed ID: 175262.
    Abstract:
    To study conformational changes of protein molecules in a pre-denaturation temperature range, nitroxyl radicals adsorbed by a protein are suggested to be used. A spin probe technique is specially developed to be implied for this aim by using a probe specifically bound to the bovine serum albumin molecule, it was possible to reveal a dependence of the rotation correlation time of the adsorbed radical and the environment polarity on the temperature. The data obtained testify in favour of a change occurring in the intramolecular structure of the protein under study due to a temperature change within the pre-denaturation temperature range.
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