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  • Title: Polyene antibiotics in the membrane environment.
    Author: Shervani Z, Sarkar AK, Bachhawat BK.
    Journal: Indian J Biochem Biophys; 1991 Aug; 28(4):227-32. PubMed ID: 1752624.
    Abstract:
    The cytotoxic activity of the polyene antibiotics mainly depends on the appearance of the drug species which arises from drug-sterol complexation. The unsaturation and intact macrolide ring of the polyenes are the requirements for the biological activity. All the polyene antibiotics can form the complex with the sterol having 3 beta-OH group, and planar ring and a hydrophobic side chain. Aromatic polyene antibiotics with positively charged head group have been considered as most potential antifungal agents.
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