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  • Title: Changes in fetal and maternal plasma protein concentration and colloid osmotic pressure with gestation.
    Author: Lumbers ER, Moore RS, Stevens AD, Gibson KJ.
    Journal: J Dev Physiol; 1991 Jun; 15(6):347-50. PubMed ID: 1753074.
    Abstract:
    In pregnant ewes, plasma protein levels over the gestation age range of 58-141 days fell progressively (r = -0.332, P less than 0.05, n = 36) but colloid osmotic pressure (COP, mmHg) did not change significantly. In fetal sheep carried by these ewes, plasma protein levels increased with age (r = 0.85, P less than 0.00001, n = 32). COP also rose (r = 0.8, P less than 0.00001, n = 23). Since maternal COP did not change and fetal COP increased, the net transplacental COP gradient between mother and fetus decreased with increasing age (r = -0.589, P less than 0.004, n = 22). Fetal plasma protein levels can be used to calculate fetal COP while maternal plasma protein levels cannot be used to calculate maternal COP.
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