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  • Title: Spectroscopic evidence for the formation of helical structures in gas-phase short peptide chains.
    Author: Brenner V, Piuzzi F, Dimicoli I, Tardivel B, Mons M.
    Journal: J Phys Chem A; 2007 Aug 09; 111(31):7347-54. PubMed ID: 17530827.
    Abstract:
    Aminoisobutyric acid (Aib) is a synthetic amino acid known to favor the formation of 3(10) helical structures in condensed phases, namely, crystals. The intrinsic character of these helicogenic properties has been investigated on the Ac-Aib-Phe-Aib-NH2 molecule under isolated conditions, namely, in the gas phase, both experimentally by double-resonance IR/UV spectroscopy and theoretically by quantum chemistry. A convergent set of evidence, based on energetic, IR, and UV spectroscopic data as well as on analogies with the similar peptide Ac-Ala-Phe-Ala-NH2 previously studied, enables us to conclude the formation of an incipient 310 helix in these isolated systems.
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