These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of penetration enhancers on in vitro permeability of meloxicam gels.
    Author: Jantharaprapap R, Stagni G.
    Journal: Int J Pharm; 2007 Oct 01; 343(1-2):26-33. PubMed ID: 17531412.
    Abstract:
    Meloxicam (MLX) was formulated as a 0.3% hydroxypropylcellulose (Klucel) gel. The effect of four different combinations of co-solvents (ethanol, glycol-PEG-400, propylene glycol, and water) on MLX permeability was determined in vitro throughout isopropyl myristate (IPM)-saturated cellulose membranes. The gel consisting of 2.5% Klucel, propylene glycol, ethanol, and water (1:1:1) showed superior permeability properties and it was selected as the base-gel to investigate the effect of three levels of the penetration enhancers: dimethylsulfoxide (1, 5, and 10% DMSO), tween20 (1, 2, and 5% TW20), oleic acid (0.4, 1, and 5% OA), and menthol (1, 2.5, and 5% MT). In vitro permeability was determined throughout IPM-saturated cellulose membranes and human cadaver skin. DMSO and TW20 did not improve permeability of MLX compared to the control gel at any of the levels tested. Menthol produced a statistically significant (P<0.001), dose proportional increase in MLX flux with a peak at 5% (2.43+/-0.47 microg/cm2/h). Conversely, addition of OA peaked at 1% but decreased at the higher level (5%). There was no significant difference between the MLX amount recovered in stratum corneum and dermis across the different formulations tested. These findings show that the 0.3% MLX gel formulation containing 5% menthol can possibly deliver therapeutically relevant doses of MLX.
    [Abstract] [Full Text] [Related] [New Search]