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  • Title: Consequences of the natural propensity of Leishmania and HIV-1 to target dendritic cells.
    Author: Garg R, Trudel N, Tremblay MJ.
    Journal: Trends Parasitol; 2007 Jul; 23(7):317-24. PubMed ID: 17531536.
    Abstract:
    Recent studies have shown that both Leishmania and HIV type-1 (HIV-1) hijack dendritic cell (DC) functions to escape immune surveillance using an array of elaborate strategies. Leishmania has developed a variety of adaptations to disrupt cellular defense mechanisms, whereas HIV-1 targets DCs to achieve a more efficient dissemination. The capacity of Leishmania and HIV-1 to target DCs through a common cell-surface molecule, namely DC-SIGN (dendritic cell specific ICAM-3-grabbing non-integrin), points to a possible dangerous liaison between these two pathogens. This review explores our knowledge of how Leishmania and HIV-1 interact dynamically with DCs, and how they exploit this cell type for their reciprocal benefit.
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