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  • Title: Tools for efficient high-throughput synthesis.
    Author: Chighine A, Sechi G, Bradley M.
    Journal: Drug Discov Today; 2007 Jun; 12(11-12):459-64. PubMed ID: 17532530.
    Abstract:
    Here, we detail the major developments in methods and techniques that are applicable to high-throughput synthesis that have evolved over the past five years, with an emphasis on the combination of microwave-based synthesis with techniques such as polymer-assisted purification and immobilized reagents and catalysts. Other aspects, such as automation, miniaturization and flow-based synthesis, are also presented as approaches that can be used for the rapid discovery and optimization of small organic molecules.
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