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  • Title: Serum 25-hydroxyvitamin D in infantile rickets.
    Author: Arnaud SB, Stickler GB, Haworth JC.
    Journal: Pediatrics; 1976 Feb; 57(2):221-5. PubMed ID: 175345.
    Abstract:
    In small children with nutritional vitamin D deficiency, the serum concentration of 25-hydroxyvitamin D (25-OH-D), the major circulating metabolite of vitamin D, was correlated with the stage of clinical disease. It was low (16 to 20 ng/ml) but within the normal range in the earliest (hypocalcemic) stage of the deficiency syndrome and decreased (less than 15 ng/ml) in the more advanced stages. In patients with familial hypophosphatemia (X-linked dominant), mean serum 25-OH-D concentration was the same as in age-matched normal controls. Evidence is presented that endogenous parathyroid hormone may have a role in the depletion of serum 25-OH0D in deficiency states.
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