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  • Title: The plaque and gingivitis reducing effect of a chlorhexidine and aluminium lactate containing dentifrice (Lacalut aktiv) over a period of 6 months.
    Author: Rathe F, Auschill TM, Sculean A, Gaudszuhn Ch, Arweiler NB.
    Journal: J Clin Periodontol; 2007 Aug; 34(8):646-51. PubMed ID: 17535285.
    Abstract:
    AIM: The aim of the study was to determine the plaque and gingivitis reducing effect of a dentifrice containing chlorhexidine and aluminium lactate compared with a control toothpaste during the course of 6 months. MATERIAL AND METHODS: This randomized, double-blind study looked prospectively at participants over a 6-month period. Plaque, gingivitis, calculus formation and tooth staining were assessed in 59 participants, who were divided into parallel groups. The participants used either a chlorhexidine and aluminium lactate-containing toothpaste (test group) or a minus active control toothpaste (control group). Parameters were assessed at baseline and again after 1, 3 and 6 months. RESULTS: After 6 months of product use, both groups had less gingivitis compared with the baseline evaluation (p<0.001). At this time point, the test group showed a statistically significant lower gingival index values compared with the control group (p=0.001). No statistically significant differences between either the groups or time points were detected with regard to plaque index and the development of calculus and staining. CONCLUSION: Although there was a statistically significant difference at 6 months between test and control groups, this difference was too small to be considered clinically meaningful.
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