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  • Title: [Clinical analysis of infectious complications following abdominal cluster transplantation].
    Author: Chen HX, Yin L, Peng CH, Zhou GW, Shen BY, Chen GM, Chen CQ, Zhou HJ, Li HW.
    Journal: Zhonghua Wai Ke Za Zhi; 2007 Mar 01; 45(5):319-22. PubMed ID: 17535710.
    Abstract:
    OBJECTIVE: To investigate the characteristic and management of postoperative infection in abdominal cluster transplantation. METHODS: Preliminary experience of two cases of abdominal cluster transplantation including small intestine was reviewed. RESULTS: Combination of five immunosuppressive agents based on tacrolimus was used. Severe Gram-negative bacillus infections occurred. The majority of invasive fungal infections was due to Candida species. Cytomegalovirus (CMV) infection increased monocytes and caused eosinopenia and an inversion of the CD4(+) to CD8(+) cell ratio in recipient I, and human CMV matrix proteins pp71 (CMV-pp71) was detected and identified in bile by PCR. Microabscesses in liver transplant biopsies were presented. CONCLUSIONS: Infectious complications after cluster transplantation were complicated. Strategies to optimize the immunity suppression protocol and early diagnosis and treatment will be important to reduce infection after abdominal cluster transplantation.
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