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  • Title: [Homocysteine decreases the invasion in cultured human trophoblasts: relationship between homocysteine and matrix metalloproteinase-2, -9 expression].
    Author: Yang PF, Li JK, Xiong Q.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 2007 Mar; 42(3):184-6. PubMed ID: 17537305.
    Abstract:
    OBJECTIVE: To test the hypothesis that homocysteine can decrease MMP-2 and MMP-9 expression in cultured trophoblasts of early pregnancy and that homocysteine can prevent trophoblasts invasion in the early stage of preeclampsia. METHODS: Cytotrophoblasts from early pregnancy were isolated and cultured. Trophoblasts were treated with or without Hcy (1 mmol/L) for 48 hour, and real time RT-PCR and gelatin zymography were used to quantify the mRNA and protease activity of MMP-2, -9. RESULTS: Treatment with Hcy (1 mmol/L) induced a decrease in MMP-2 mRNA by 21% and MMP-9 mRNA by 11%. At protein level MMP-2 expression decreased 14% and MMP-9 expression decreased 52% compared with control. CONCLUSIONS: Homocysteine can decrease MMP-2, -9 expression in trophoblasts of early pregnancy and influence its invasion process.
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