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  • Title: Sequence variability in the FUM1 gene of Fusarium verticillioides strains.
    Author: da Silva VN, de Araujo J, Durigon EL, Corrêa B.
    Journal: Can J Microbiol; 2007 Mar; 53(3):446-9. PubMed ID: 17538656.
    Abstract:
    Fumonisins are mycotoxins, produced mainly by Fusarium verticillioides, that are potentially carcinogenic to humans and toxic to animals. Synthesis of these toxins is directed by a cluster of 15 genes, among which FUM1 is the largest; it encodes a polyketide synthase. This enzyme probably catalyzes the synthesis of a polyketide that forms a large portion of the fumonisin structure. In this study, 27 strains possessing the FUM1 gene, as determined by polymerase chain reaction, were analyzed. A portion of the FUM1 gene was amplified and sequenced from 6 of 27 Brazilian strains isolated from corn and sorghum. The sequence similarity for the six F. verticillioides strains was almost 100%.
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