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  • Title: In situ micro-sized gel-forming injectable implant using biodegradable amphiphilic graft copolymer.
    Author: Cho KY, Lee S, Park JK.
    Journal: Macromol Biosci; 2007 Jun 07; 7(6):784-8. PubMed ID: 17541923.
    Abstract:
    A synthesized graft polymer is used as a biodegradable polymer for an in situ gel-forming injectable implant system. The amphiphilic character of the polymer in the graft structure lowered the viscosity of the polymer solution, which enabled easy injection. A micro-sized gel can be obtained with this system, which has not been found for previous in situ gel-forming systems with poly[(D,L-lactide)-co-glycolide] copolymer. In addition, a protein particle embedded gel exhibits good in vitro drug release performance as a result of the enhanced stability and shorter diffusion length.
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