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  • Title: Oxime and oxime ether derivatives of 1,4-benzothiazine related to oxiconazole.
    Author: Milanese L, Giacchè N, Schiaffella F, Vecchiarelli A, Macchiarulo A, Fringuelli R.
    Journal: ChemMedChem; 2007 Aug; 2(8):1208-13. PubMed ID: 17541993.
    Abstract:
    The synthesis, in vitro antifungal activity, and molecular docking experiments of some oxime and oxime ether derivatives of azole 1,4-benzothiazine are reported herein, with the aim of evaluating the influence of a partially constrained scaffold that is structurally related to Oxiconazole and bearing the 1,4-benzothiazine moiety, on the inhibition of Candida albicans CYP51.
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