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  • Title: [Neumopathies in patients with primary immunodeficiencies in treatment with intravenous gammaglobulin].
    Author: Mogica Martínez MD, García Lara S, Silva Vera R, Montaño Velázquez B, Cruz Mérida A, Santibáñez Bustamante J, Moreno Martínez JM.
    Journal: Rev Alerg Mex; 2007; 54(1):14-9. PubMed ID: 17542250.
    Abstract:
    BACKGROUND: The primary immunodeficiency diseases cause a deficit in the production of antibodies. The chronic sinopulmonary disease is common and their clinic symptoms are diverse (pneumonia, bronchiectasis). OBJECTIVE: To know the frequency and type of pulmonary abnormalities in patients with primary immunodeficiency in treatment with intravenous immunoglobulin. MATERIAL AND METHODS: 24 files of patients with primary immunodeficiency were selected. Age, sex, primary immunodeficiency type, time of immunoglobulin treatment, chest X-ray finding, pulmonary computed tomography of high resolution (HRCT) and pulmonary function tests were registered. Measures of central tendency were calculated. RESULTS: There was no predominance of gender; the average age was 14 years old. The common variable immunodeficiency and the Bruton's hypogammaglobulinemia represented 91% of the patients. The X-ray of thorax was abnormal in 33%, although there were not bronchiectasis. The high-resolution computed tomography scan (HRCT) was abnormal in 67%, and 75% had bronchiectasis. CONCLUSIONS: The pulmonary complications are common despite therapy with intravenous immunoglobulin. The HRCT is better than X-ray in these patients.
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