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  • Title: Energy regulation: HIF MXIes it up with the C-MYC powerhouse.
    Author: Sutphin PD, Giaccia AJ, Chan DA.
    Journal: Dev Cell; 2007 Jun; 12(6):845-6. PubMed ID: 17543856.
    Abstract:
    The phenomenon of aerobic glycolysis observed in cancer cells has remained unexplained. In the May 2007 issue of Cancer Cell, Zhang and colleagues determine that the hypoxia-inducible factor family of transcriptional factors regulate mitochondrial biogenesis through inhibition of C-MYC.
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